Portrait of the immune system: history and perspective
Instituto Gulbenkian de Ciência, November 29-30, 2011

Oral Presentations

(15 minutes plus 5 min discussion)

CD70 on dendritic and epithelial cells in the thymic medulla promotes CD4 Foxp3 regulatory T cell development via CD27
Julie C. Ribot1,*, Jonathan M. Coquet2,*, Sabine Middendorp2, Gerda van der Horst2, Yanling Xiao2, Nikolina Babala2, Joana F. Neves3,  Daniel J. Pennington3, Heinz Jacobs2, Jannie Borst2,** and Bruno Silva-Santos1,**

Clonal Analysis of V(D)J Rearrangement in Immunoglobulin Genes: Implications for Allelic Exclusion
Clara F.A. Pereira1, Paulo Vieira2, Vasco M. Barreto1

Generation of anti-inflammatory adenosine by leukocytes is regulated by TGF-β
Frederico S Regateiro, Duncan Howie, Kathleen F Nolan, Eleftherios I Agorogiannis, David R Greaves, Stephen P Cobbold, Herman Waldmann

HIV-2 has a reduced ability to infect the human thymus.
Helena Nunes-Cabaço, Rita Tendeiro, Russell B. Foxall, Rui S. Soares, Ana I. Pinheiro, Paula Matoso, Ana E. Sousa

Host IL-10 production is responsible for neonatal mice susceptibility against Group B Streptococcus infections
Pedro Madureira 1,2, Elva Bonifácio Andrade 1,2, Liliana Oliveira 1,2, Adília Ribeiro 1,2, Margarida Correia-Neves 3, Patrick Trieu-Cuot 4, Manuel Vilanova 1,2

Infected but not Bystander Dendritic Cells polarize CD4 T cells towards a non-protective T-bet INF-γ IL10 phenotype
Mariana Resende1, Diana Moreira1, Joana Cunha1,2, Bruno Neves3,4, Maria Teresa Cruz3,4, Anabela Cordeiro da Silva1,5 and Ricardo Silvestre1

Lympho-stromal interactions decline the frequency of IL-7-expressing thymic epithelial cells independently of the establishment of the medullary epithelium compartment.
Ana Rosalina Ribeiro1, Heidi Schmid1, Pedro Rodrigues1, Alexandra Moreira1, Alexandre do Carmo1, James P. Di Santo2, Nuno Lages Alves1

Posters

(height: 115 cm ; width: 85 cm)

Molecular mechanisms of differentiation of pro-inflammatory gamma-delta T cell subsets
Nina Schmolka1, Anita Q. Gomes1,2,3 and Bruno Silva-Santos1

CD6 inhibits T cell signaling
Carine M. Gonçalves1,2*, Marta I. Oliveira1*, Mafalda Pinto1, Stéphanie Fabre3,4, Georges Bismuth3,4, Alexandre M. Carmo1,2

Notch signaling enhances the in vitro differentiation of human Regulatory T cells
Catarina Mota, Vânia Silva, Rui M. M. Victorino, Ana E. Sousa and Iris Caramalho

Selective effects of NF-κB1 deficiency in CD4 T cells on the induction of Th2 and TFh cell functions
Karine Serre1, Elodie Mohr2, Adam F. Cunningham3, Roger Bird3, Mahmood Khan3, Cécile Benezech3, Jorge H. Caamaño3 and Ian C. M. MacLennan3

Serum immunoglobulins play a role in B cell homeostasis
Andreia C. Lino1, Elodie Mohr1, Jocelyne Demengeot1

T cell Maturation Stage Conditions de novo Foxp3 Expression in vivo
Paiva RS, Lino AC, Bergman ML, Zelenay S, Demengeot J

Activation of IL-27 p28 gene transcription on antigen presenting cells infected with Leishmania infantum  
Robalo AL1,2, Pereira JA1,3, Resende M1, Moreira D1, Cunha J1,4, Costa-Lima S1, Cordeiro-da-Silva A1,5 and Silvestre R1

BAFF-R and TACI expression in Common Variable Immunodeficiency – insights into receptor dynamics
Rita R. Barbosa1, Susana L. Silva1,2, Sara P. Silva1,2, Alcinda Campos Melo1, Conceio Pereira-Santos1, João T. Barata3, Ana E. Sousa1

Cytokine expression during RHD: differences between adult and young rabbits
R. M. Marques1, L. Teixeira1,2, A. Costa-e-Silva1,2, A. P. Águas1,2, P. G. Ferreira1,2

Cytoplasmic domains of CD5 control its localization at the immunological synapse
Ana Mafalda Santos1, Bruno Guimarães1, Franscisco Lozano2, Alexandra Moreira1, Georges Bismuth3, Simon J. Davis4, Alexandre M. Carmo1

Differentiation of human peripheral blood Vδ1 T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells
Daniel V. Correia1, Manuela Fogli2, Kelly Hudspeth2, Maria Gomes da Silva3, Domenico Mavilio2, and Bruno Silva-Santos1

Differentiation of human peripheral blood Vδ1 T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells.
Correia DV1, Fogli M2, Hudspeth K2, da Silva MG3, Mavilio D2, Silva-Santos B1.

Fetal Innate Immunity Factors reveal a protective role in a murine model of Pregnancy-Associated Malaria (PAM)
Rodrigues-Duarte, L.; Moraes, L.V.; Penha-Gonçalves, C.

Group B Streptococcus GAPDH is released upon cell lysis, associates with bacterial surface, and induces apoptosis in murine macrophages
Liliana Oliveira1,2,3,4, Pedro Madureira1,2, Elva Bonifácio Andrade1,2, Abdelouhab Bouaboud3,4, Eric Morello5, Paula Ferreira1,2, Claire Poyart3,4, Patrick Trieu-Cuot5 and Shaynoor Dramsi5

HIV unveils: regulated vesicle fusion conveys T cell receptor signaling
1,2Helena Soares, 3Leandro Ventimiglia, 3Olga M. Anton, 4,5Françoise Porrot, 6,7,8Ricardo Henriques, 3Miguel A. Alonso, 4,5Olivier Schwartz, 1,2Maria-Isabel Thoulouze* and 1,2Andrés Alcover*

Immunoglobulin secretion is required for plasma cell maturation in steady states
Andreia C. Lino1, Jocelyne Demengeot1 and Elodie Mohr1

Impact of common-gamma chain cytokines on human thymic regulatory T cell development
Iris Caramalho1, Vânia Nunes-Silva1, Ana Rita Pires1, Ana Isabel Pinto2, Catarina Mota1, Helena Nunes-Cabaço1 and Ana E. Sousa1

Intravital imaging acquisition of uterus: the mystery of DC distribution before implantation
Susana S. Caetano and Carlos E. Tadokoro

Lymphoid tissue inducer (LTi)-like cells in human tonsils and colon mucosa
Susana M. Fernandes1,3, Ana R. Pires1, Russell B Foxall1, Cristina Ferreira2, Henrique Veiga-Fernandes4, Ana E. Sousa1

Pathologic Consequences of Heme Release from Hemoproteins
Zélia Gouveiaab, Olga Iranzoa, Smilja Todorovica, Miguel Soaresb

Peripheral administration of foreign antigens promotes a dose dependent intrathymic selection of specific regulatory T cells.
Marie-Louise Bergman, Ricardo Sousa Paiva, Santiago Zelenay and Jocelyne Demengeot.

Plasmin(ogen) acquisition at the surface of Group B Streptococcus promotes the invasion of the Central Nervous System
Vanessa Magalhães1,2,3, Joana Alves1,2, Elva Bonifácio Andrade1,2, Adília Ribeiro1,2, Kwang Sik Kim4, Patrick Trieu-Cuot5 and Paula Ferreira 1,2

Regulatory T cells are decreased in RHDV infection
Luzia Teixeira1,2, Raquel M. Marques1,2, Sara Cunha1,2, Artur P. Águas1,2, Paula G. Ferreira1,2

Role Of Haptoglobin And Its Polymorphism In Bronchial Asthma
Margarida Cortez1;Joana Ferreira2;M.A.Pereira-Barbosa1 ;Manuel Bicho2; Cláudia Marinho2

Skin-regulatory T cell disturbance after Plasmodium berghei sporozoite infection
Henrique Borges da Silva1,2, Susana Caetano1, Isadora Monteiro1, Iván Gómez Conde3, Kirsten Hanson4, David Olivieri3, Maria M. Mota4, Cláudio R. Marinho5, Maria R. D'Imperio Lima2, Carlos E. Tadokoro1

Th1-type immune response elicited in the intestinal mucosa of mice infected intragastrically with Neospora caninum
Alexandra Correia1, Pedro Ferreirinha1, Joana Melo1, Catarina Meireles1, Ana Amorim1, Adília Ribeiro1,2, Luzia Teixeira1,3, África González4, Manuel Vilanova1,2

The fate of CD4 T cells under tolerogenic stimulation: a modeling perspective
M. Caridade1, V. Oliveira1, A. Agua-Doce1, R.M. Ribeiro2, L. Graca1

The role of B1 cells in the early steps of type 1 diabetes
Nadia Duarte, Joana Côrte-Real, Carlos Penha-Goncalves

Uncovering the role of IFNAR1 in Experimental Cerebral Malaria
Elizabeth Ball, Carlos Penha Goncalves

UNDERSTANDING THE DUAL ROLE OF MURINE GAMMA-DELTA T CELLS IN TUMOR IMMUNE SURVEILLANCE
Telma Lança 1*, Margarida Rei 1,2* , Daniel J Pennington 2, Bruno Silva-Santos1,3

Vβ Repertoire at the TCRβ locus:   Contribution of the Recombination Signal Sequence    and the Epigenetic Marks to the Recombination Efficiency
M. Bonnet1, S. Spicuglia2, P. Ferrier3, J. Carneiro1, J. Demengeot1