Jorge is a theoretical biologist who uses mathematical models to understand the dynamical behaviour of cells and cellular collectives. He is a group leader at the Instituto Gulbenkian de Ciência (IGC), where he heads the Quantitative Organismal Biology group.
Jorge got his degree in Biochemistry from the University of Porto, Portugal, in 1991. He prepared his PhD at the Pasteur Institute in Paris, where he developed immune network models incorporating B and T lymphocytes with John Stewart. He got his PhD in 1997 from the University of Porto. After a short postdoc at the University of Utrecht, with Rob de Boer, he became an independent researcher at IGC in April 1998. In 2010, he did a sabbatical at the Institute of Biotechnology of the UNAM, Mexico, with Alberto Darszon.
Jorge's group was at the forefront of theoretical and quantitative studies on the dynamics of regulatory T cells, the cells that prevent of autoimmune pathologies in healthy individuals. Together with his collaborators, he predicted the mechanism of action and repertoire selection of these cells, embodied in the Crossregulation Model. His vision of the way the immune system tolerates the organism's tissues and rejects extraneous or pathogen-infected tissues was successfully implemented as spam detection algorithms and fault-robust multiagent systems. Jorge gained interest in modelling the form and morphodynamics of cells and tissues during development, and on the quantitative imaging techniques necessary to assess these models.
Jorge is active in the scientific community. He often organises workshops and courses on scientific topics such as biostatistics, mathematical and computational biology, immunology and imaging, as well as topics that are relevant for (young) scientists such as career development and entrepreneurship. Between 1998 and 2004, he was a member of direction of the Portuguese Society of Immunology, acting as Secretary General and Vice-President in the first and second triennia, respectively. He participated in the organisation of and fundraising for the PhD Program in Computational Biology and eventually became its Director. This pilot programme was launched in 2005 being promoted by FCG, FCT and Siemens SA, and further sponsored by FCCN and Fundação PT. Between 2013 and 2018, Jorge acted as Deputy Director for Science of the Instituto Gulbenkian de Ciência.