Lectures in the MolecularSystems Biology Course
Doctoral Programme in Experimental Biology and Biomedicine (BEB), University of Coimbra
November 14-18, 2011
Lecturers
Jorge CarneiroBio
Instituto Gulbenkian de Ciencia, Oeiras, Portugal
Lectures
Wednesday, November 16, 2011
Morning: Integrating molecular, cellular and collective dynamics of a multicellular system: the regulatory CD4 T lymphocytes case study
Lecture 1. The crossregulation model of the dynamics of regulatory CD4 T lymphocytes populations
Lecture 2. Regulatory gene network controling the differentiation of CD4 T lymphocytes
Lecture 3. Integrating molecular and cellular networks: from tissue to genes and back.
Afternoon: The sensorimotor system of a single cell
Lecture 4. Swimming and chemotactic behavior of sea urchin spermatozoa
Lecture 5. Modelling the signalling, morphodynamics and swimming mechanics of a spermatozoon
Lecture 6. And this is how a sea urchin spermatozoon find its conspecific egg
Bibliography
Léon, K., R.Perez, A.Lage
& J.Carneiro. (2000). Modelling T cell mediated suppression dependent
on interactions in multicellular conjugates. J.Theor.Biol. 207, 231-254. [PDF 412KB]
Carneiro J. , K. Leon, I. Caramalho, C. van den Dool, R. Gardner, V. Oliveira, M.-L. Bergman, N. Sepulveda, T. Paixao, J. Faro, and J. Demengeot. (2007) When three is not a crowd: A crossregulation model of the dynamics and repertoire selection of regulatory CD4 T cells. Immunol. Reviews216, 48-68. [PDF 2.9Mb]
Naldi, A., J. Carneiro, C. Chaouiya, and D. Thieffry. (2010) Diversity and plasticity of Th cell types predicted from regulatory network modelling. PLoS Comp. Biol.6, e1000912. [PDF 528Kb]
Guerrero, A., J. Carneiro, A. Pimentel, C.D. Wood , G. Corkidi, A. Darszon. (2011) Strategies for locating the female gamete: the importance of measuring sperm trajectories in three spatial dimensions.
Mol. Hum. Reprod.17, 511-23. [PDF 488Kb]
Guerrero, A., T. Nishigaki, J. Carneiro, Y. Tatsu, C.D. Wood, and A. Darszon. (2010) Tuning sperm chemotaxis by calcium burst timing. Dev. Biol.344, 52-65. [PDF 1Mb]
